By Laurence Klotz M.D., F.R.C.S.C. (auth.), Laurence Klotz (eds.)
Active Surveillance for Localized Prostate melanoma: a brand new Paradigm for medical administration will function an invaluable source for physicians facing, and drawn to, this complicated and evolving department of prostate melanoma administration. The publication can be of curiosity to scientifically literate sufferers and their households. the quantity offers an creation to the idea that of lively surveillance in oncology mostly and prostate melanoma particularly. the first concentration is to supply a complete consultant to the administration of sufferers on surveillance. the quantity covers the numerous complexities and nuances to this process together with, sufferer choice, hazard evaluation, tips to triumph over 'cancer hysteria' whilst counseling sufferers, opting for applicable triggers for intervention, use of PSA kinetics and MR imaging info, approach and frequency of biopsies, secondary prevention interventions, and the relative roles of surveillance and focal therapy.
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Additional resources for Active Surveillance for Localized Prostate Cancer: A New Paradigm for Clinical Management
76. Period Life Table, 2006. html]. 77. Clayton DB, Urban DA. Point: the value of predicting life expectancy in men with clinically localized prostate cancer. J Natl Compr Canc Netw. 2007 Aug;5(7):703–8. 78. Steineck G, Helgesen F, Adolfsson J, et al. Quality of life after radical prostatectomy or watchful waiting. N Engl J Med. 2002 Sep 12;347(11):790–6. 21 79. Litwin MS, Lubeck DP, Spitalny GM, Henning JM, Carroll PR. Mental health in men treated for early stage prostate carcinoma: a posttreatment, longitudinal quality of life analysis from the Cancer of the Prostate Strategic Urologic Research Endeavor.
J. Donovan and C. Cordon-Cardo Fig. 2 Utilizing multiplex immunofluorescence, a series of protein biomarkers including cytokeratin 18 (CK18), alpha-methyl CoA racemase (AMACR), and the androgen receptor (AR) are evaluated in FFPE prostate needle biopsy tissue sections. Nuclear AR profiles (white dots) are first examined as grayscale images (a). The grayscale views are processed using a layering algorithm which outlines CK18 positive epithelial gland structures and then overlays +/− AMACR (green) and annotates epithelial nuclear AR (red) (b).
Pathology. 2010;42:384–94. 7. Ding Z, Wu C-J, Chu GC, Xiao Y, Ho D, Zhang J, Perry SR, Labrot AS, Wu X, Lis R, Hoshida Y, et al. SMAD4dependent barrier constrains prostate cancer growth and metastatic progression. Nature. 2011;470:269–73. 8. Lewinshtein D, Porter CR, Nelson P. Genomic predictors of prostate cancer therapy outcomes. Expert Rev Mol Diagn. 2010;10:619–36. 9. Ahmed H. Promoter methylation in prostate cancer and its application for the early detection of prostate cancer using serum and urine samples.
Active Surveillance for Localized Prostate Cancer: A New Paradigm for Clinical Management by Laurence Klotz M.D., F.R.C.S.C. (auth.), Laurence Klotz (eds.)